In his book, “The End of Your World”, Adyashanti asks this question and wants us to ponder it before answering right away. Off the cuff, I would say nothing really that I am certain of except that my physical body will eventually die. I guess taxes, but at one time in past history were there taxes or human bodies on planet Earth? and there is always the possibility of our nonexistence in human form on Earth if we don’t awaken collectively fast enough.
It’s okay to have preference, beliefs, judgments, opinions, and assumptions, etc. with discussions amongst ourselves, different communities, and nations to learn and grow from one another as long as we don’t form attachments to them and they become a part of our individual or collective “identity”, separating ourselves from the Divine causing endless individual and collective suffering.